Can Dual Treatments Be Used for Tardive Dyskinesia?

December 11, 2018
Rakesh Jain, MD, MPH

In this occasional feature, members of the Psych Congress Steering Committee and faculty answer questions asked by attendees at Psych Congress meetings.

QUESTION: Is there any rationale for using both Austedo and Ingrezza at the same time?

Your Questions Answered logoANSWER: No. It would not be wise or prudent to use both of these medications together. Just as background—deutetrabenazine (Austedo) and valbenazine (Ingrezza) have been approved for the treatment of tardive dyskinesia by the FDA. You are welcome to use either one of these medications with or without concurrent therapy with any antipsychotic medication. There is no reason to combine these medications, and there is significant reason to believe that using them together might lead to significant side effects for the patient. This concern is both at the pharmacodynamic and pharmacokinetic level.

You may want to optimize the dosage of either medication first, and if that proves to be sub-optimum for any reason (efficacy or side-effect challenges), then consider a switch to the other medication. But using them together is not appropriate and could be quite harmful.

— Psych Congress cochair Rakesh Jain, MD, MPHClinical Professor, Department of Psychiatry, Texas Tech Health Sciences Center School of Medicine, Midland


MORE QUESTIONS ANSWERED:

Treating Patients With Long-term Tardive Dyskinesia

Does Tardive Dyskinesia Severity Impact the Effectiveness of Treatments?

Can TD Occur in Patients Who Never Took Typical Antipsychotics?

Do TD Medications Decrease the Effectiveness of Antipsychotics?