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Tardive Dyskinesia Symptoms Lower Quality of Life

September 25, 2017

NEW ORLEANS—Tardive dyskinesia (TD) symptoms in patients with schizophrenia, bipolar disorder, or major depression are linked with deficits in physical, mental, and social functioning, according to a poster presented at Psych Congress 2017.

“Among patients with psychiatric disorders, tardive dyskinesia is associated with significant physical health burden and incremental mental health burden,” researchers wrote. “Tardive dyskinesia severity is also associated with lower overall quality of life and greater social withdrawal.”

Researchers formed their findings after administering questionnaires to 169 adults with clinician-confirmed schizophrenia, bipolar disorder, or major depressive disorder. Of the participants, 79 had TD and 90 did not. The groups were similar in age, gender, and the number of patients who had each disorder.

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Patients with TD scored significantly worse on the physical component summary of the SF-12v2 Health Survey, the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form, and the social withdrawal subscale of the Internalized Stigma of Mental Illness scale, researchers reported, compared with patients without the movement disorder. The difference in the physical component summary scores exceeded the established minimal clinically important difference of 3 points, researchers pointed out.

When stratified by the severity of TD symptoms, participants with more severe symptoms had significantly worse scores on the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form and the social withdrawal subscale of the Internalized Stigma of Mental Illness scale, compared with participants with less severe symptoms.

Differences in the physical and mental component summaries of the SF-12v2 Health Survey were in the expected direction, researchers added, and also exceeded the minimal clinically important difference of 3 points.

The poster was sponsored by Teva Pharmaceutical Industries, makers of TD therapy deutetrabenazine.

—Jolynn Tumolo

Reference

McEvoy J, Carroll B, Gandhi S, et al. Effect of tardive dyskinesia on quality of life: self-reported symptom severity is associated with deficits in physical, mental, and social functioning. Poster presented at Psych Congress 2017; September 16-19, 2017; New Orleans, LA. Poster 256.

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