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Psych Congress  

Response Patterns for Digital Medicine Missed Dose Surveys in Patient with Serious Mental Illness

Authors  

Jonathan Knights, Ph.D. – Otsuka Pharmaceutical Development & Commercialization, Inc.; Zahra Heidary, Ph.D. – Otsuka Pharmaceutical Development & Commercialization, Inc.

Sponsor  
Otsuka Pharmaceutical Development & Commercialization, Inc.

Introduction: Digital medicine consists of the integration of active pharmaceuticals and wearable/ingestible sensors combined with mobile and web-based tools with the expectation of improving the management of medication adherence. Reporting and understanding response patterns to missed dose surveys on these systems is critical to developing better understanding around patient ingestion behaviors.

Methods: Unobserved dose survey data from two clinical trials (NCT02722967, NCT02219009) were used. In the digital medicine system, a patient is prompted with a pre-defined set of (five) potential reasons for why an ingestion was unobserved on a particular (prior) day. Summary statistics at both the response- and patient-level were derived, and the relevant distributions are presented and discussed.

Results: 112 patients with serious mental illness recorded 1392 surveys across an 8-week treatment period, with a median per-patient observed survey count of 10. Approximately 81% of these survey responses chose “I took my dose, but it did not register”, with 48% of the patient population selecting this option at every prompt. There was a skewed U-shaped distribution in the percentage of surveys sent to patients across the days of the week, with Friday having the fewest percentage of patients receiving a survey, and Monday having the highest.

Conclusions: These results indicate there may be weekly rhythms to ingestion success rates. Additionally, patients’ currently appear to default to reporting system error. We have previously observed patients reporting this option and subsequently returning unopened medication, highlighting potential sensitivities from the patient’s perspective to be transparent with their medication taking behavior.

This poster was presented at the 32nd annual Psych Congress, held Oct. 3-6, 2019, in San Diego, California.

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