Bipolar Depression


Vladimir Maletic

Dextromethorphan (DM) has long been in use as an ingredient in cough medicines. More recently, in combination with quinidine (DM/Q), it has been approved as a treatment for pseudobulbar affect. But what does the research say about using it to treat mood disorders?

Women with polycystic ovary syndrome (PCOS) are at increased risk of depression, anxiety, bipolar disorder, and eating disorders, according to a large case-control study from the UK.


A study of pharmacologic treatments found the mood stabilizer lithium the most effective at lowering the risk of rehospitalization in patients with bipolar disorder. 

FDA approved

The FDA has approved a supplemental New Drug Application for the treatment of major depressive episodes associated with bipolar disorder in patients aged 10 to 17 years.

The brain in people with early-stage schizophrenia, but not bipolar disorder, ages more quickly than normal, new research suggests.



Charles L. Raison, MD; Andrei Pikalov, MD, PhD; Cynthia Siu, PhD; Joyce Tsai, PhD; Kenneth Koblan, PhD; Antony Loebel, MD
Joseph R. Calabrese, MD; Na Jin, MS; Brian Johnson, MS; Peter Hertel, PhD; Pedro Such, MD; Jocelyn Ottinger, BS; Joan Amatniek, MD
Willie Earley, MD; Suresh Durgam, MD; Kaifeng Lu, PhD; György Németh, MD; Akshar Patel, MD; István Laszlovszky, PharmD, PhD
Andrei Pikalov, MD; PhD; Joyce Tsai, PhD; Yongcai Mao, PhD; Josephine Cucchiaro, PhD; Antony Loebel, MD