Major Depressive Disorder

A new cohort study confirmed a previously reported association between treatment with antidepressants and hip fracture in older adults, but it contained a twist.


Over time, untreated major depressive disorder (MDD) changes a person’s brain, according to brain imaging research published online in The Lancet Psychiatry.

Ketamine and other glutamatergic drugs produce rapid antidepressant effects, a new evidence review reports, but questions about the agents and their ramifications persist.

marijuana user

Compared with 50 years ago, cannabis products today contain increased amounts of tetrahydrocannabinol (THC), the cannabinoid responsible for the high marijuana users experience, according to a research analysis.

A healthy diet full of vegetables, fruit and whole grains is tied to a lower risk for depression in the elderly, according to preliminary research.

New guidelines endorsed by the American Academy of Pediatrics aim to support primary care clinicians in managing adolescent depression.




"Have you seen interferon precipitate mania in a patient?"


"I have recently heard a lecture about "pseudounipolar" depression. Does this form of mood disorder really exist?"



Peter Werner PhD, Joseph Goldberg MD, Andrei Pikalov MD, PhD, Kei Watabe MS
Ken O'Day PhD, MPA, Mariam Hassan PhD, Krithika Rajagopalan PhD, Kellie Meyer PharmD, MPH
Mary Bond, MS, MBA, Ronghua Yang, PhD, Edward T. Hellriegel, PhD, Philmore Robertson, Jr., PhD
Richard Shelton, MD, Stephen Stahl, MD, PhD, George Papakostas, MD, John Zajecka, MD
Angela Dinkins Smith, PhD, Marc Cooper, MD, Neil Page, MD