Major Depressive Disorder

A new cohort study confirmed a previously reported association between treatment with antidepressants and hip fracture in older adults, but it contained a twist.


Patients with major depressive disorder (MDD) treated with the anticonvulsant ezogabine demonstrated a significant drop in depressive symptoms and an increase in resilience in a small trial described online in Molecular Psychiatry.

Cognitive behavioral humanistic and interpersonal training (CATCH-IT) may be better than health education as a primary care intervention to reduce risk in adolescents with subsyndromal depression, researchers say.

The benefits of Sage Therapeutics Inc's experimental treatment for postpartum depression outweigh risks, an advisory panel to the U.S. Food and Drug Administration said.

In a small group of patients with major depressive disorder and symptoms of insomnia, treatment with the antidepressant vortioxetine significantly improved depression and sleep issues.

ORLANDO, Fla.—Data on esketamine nasal spray, focusing on efficacy, tolerability, and predictors of response and remission, were presented in 4 poster abstracts at Psych Congress 2018.



Tips to assist a self-referred physician who comes to us should he/she be accused of unacceptable, abusive, oppositional, or bullying behavior in the workplace.

Here are some ways in which physicians can assist when medical communities are trying to cope with the loss of a physician colleague who has killed herself/himself.

As members of the mental health field, we can be of great assistance when contacted by someone in leadership that a physician in their midst i.e. one of their own, has died by suicide.



David G. Brock, MD; Alvaro Pascual-Leone, MD, PhD; Mark A. Demitrack, MD
Katalin Berlow, HSD; Andrew Valadez, BS; Rustin Berlow, MD
Anita Loughlin, PhD; Nancy Lin, ScD; Victor Abler, DO; Benjamin Carroll, PharmD
Allen Doederlein, BA; Ingrid Deetz, BA; Denisse DePeralta, BA; Brittany Telander, BBA, BFA; Halli Benson; Xiaowu Sun, PhD; Jyotsna Mehta, BPharm, MS; Anna Skabeev, MD, MBA; Nikki Levy, BS; Mugdha Gore, BPharm, PhD
Larry Ereshefsky, PharmD, FCCP, BCPP; Kristian Tore Jørgensen, PhD; Maëlys Touya, PharmD; Alex Rubin, MS; Delphine Saragoussi, MD, MScPH; Clément François, PhD



David E. Nichols, PhD, talks with Charles Raison, MD, about how ketamine works at the receptor level to produce powerful and rapid antidepressant effects. Click through to watch the video and read a transcript.

Charles Raison, MD, interviews Gerard Sanacora, MD, PhD, about a common clinical scenario—a patient in your office requests ketamine, an experimental treatment. What do you do?