Major Depressive Disorder

A new cohort study confirmed a previously reported association between treatment with antidepressants and hip fracture in older adults, but it contained a twist.


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A systematic review of 10 studies found that people with depression and which comorbid condition experienced little to no relief from depression symptoms when taking antidepressants?

A 60-hour infusion of brexanolone significantly improves symptoms in women with postpartum depression, according to results from two phase 3 trials.

Women going through the menopausal transition should be evaluated and treated for depression, advise the first-ever clinical recommendations on evaluating and treating perimenopausal depression.

Adolescents with lower white matter density in the brain at age 14 were more likely to develop depression at age 16, suggesting reduced white matter density may be a depression vulnerability biomarker.

By the time they reach young adulthood, people with autism spectrum disorders are at increased risk for depression, compared with the general population, according to a new study.



The biblical proverb ‘Physician, heal thyself’ is interpreted literally by some psychiatrists who reach for pharmaceutical samples if they find themselves slipping into a depression.

When Robin Williams committed suicide this week, he shocked a nation who had delighted for years in the bright light of his rapid-fire, witty humor. How should we as mental health professionals respond to such a public suicide?

In standard TMS, direct neuronal activation is limited to a depth of about 1.5 cm in cortical regions. With Deep TMS, the different design of the coil system allows for greater penetration and direct neuronal activation up to a depth of 6 cm, permitting direct excitation or inhibition of deeper brain structures.



Maëlys Touya, MSc, PharmD; Françoise Diamand, MSc; Delphine Saragoussi, MD, MScPH; Clément François, PhD; Christophe Lançon, MD, PhD
Andrei Pikalov, MD, PhD; Joyce Tsai, PhD; Yongcai Mao, PhD; Michael Tocco, PhD; Antony Loebel, MD



Scott T. Aaronson, MD, and Charles Raison, MD, discuss response rates to transcranial magnetic stimulation (TMS).

Charles Raison, MD, talks with John Mann, MD, about the current state of knowledge on suicide risk factors. To view a transcript of their conversation, click here.